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12 Myristoyl 13 acetylphorbol, 12 O Tetradecanoyl Phorbol 13 Acetate, 12-Myristoyl-13-acetylphorbol, 12-O-Tetradecanoyl Phorbol 13-Acetate, 13-Acetate, 12-O-Tetradecanoyl Phorbol, Acetate, Phorbol Myristate, Acetate, Tetradecanoylphorbol, Myristate Acetate, Phorbol, Phorbol 13-Acetate, 12-O-Tetradecanoyl, Phorbol Myristate Acetate, Tetradecanoylphorbol Acetate, Tetradecanoylphorbol Acetate, 4a alpha Isomer, Tetradecanoylphorbol Acetate, 4a alpha-Isomer

No.	Title	Href
1	PMA synergistically enhances apicularen A-induced cytotoxicity by disrupting microtubule networks in HeLa cells. BMC Cancer. 2014 Jan 22;14:36. doi: 10.1186/1471-2407-14-36.	`Click`

No.

Title

Href

PMA synergistically enhances apicularen A-induced cytotoxicity by disrupting microtubule networks in HeLa cells. BMC Cancer. 2014 Jan 22;14:36. doi: 10.1186/1471-2407-14-36.

Click

Name	Phorbol 12-myristate 13-acetate
PubChem CID	27924
Molecular Weight	616.8g/mol
Synonyms	12 Myristoyl 13 acetylphorbol, 12 O Tetradecanoyl Phorbol 13 Acetate, 12-Myristoyl-13-acetylphorbol, 12-O-Tetradecanoyl Phorbol 13-Acetate, 13-Acetate, 12-O-Tetradecanoyl Phorbol, Acetate, Phorbol Myristate, Acetate, Tetradecanoylphorbol, Myristate Acetate, Phorbol, Phorbol 13-Acetate, 12-O-Tetradecanoyl, Phorbol Myristate Acetate, Tetradecanoylphorbol Acetate, Tetradecanoylphorbol Acetate, 4a alpha Isomer, Tetradecanoylphorbol Acetate, 4a alpha-Isomer
Formula	C₃₆H₅₆O₈
SMILES	CCCCCCCCCCCCCC(=O)OC1C(C2(C(C=C(CC3(C2C=C(C3=O)C)O)CO)C4C1(C4(C)C)OC(=O)C)O)C
InChI	1S/C36H56O8/c1-7-8-9-10-11-12-13-14-15-16-17-18-29(39)43-32-24(3)35(42)27(30-33(5,6)36(30,32)44-25(4)38)20-26(22-37)21-34(41)28(35)19-23(2)31(34)40/h19-20,24,27-28,30,32,37,41-42H,7-18,21-22H2,1-6H3/t24-,27+,28-,30-,32-,34-,35-,36-/m1/s1
InChIKey	PHEDXBVPIONUQT-RGYGYFBISA-N
CAS Number	16561-29-8
ChEMBL ID	CHEMBL279115
ChEBI ID	CHEBI:37537
Drug Bank ID	DB17045
KEGG ID	C05151
Toxicity	Organism	Test Type	Route(Dose)
	rat	LD50	intraperitoneal(165 mg/kg)
	mouse	LD50	intraperitoneal(254 mg/kg)
	rat	LD50	oral(322 mg/kg)
Structure			Download 2D MOL 3D MOL

Chineses Pinyin	BaDou
Use Part	Dried seed
Habitat	SiChuan, HuNan, HuBei, YunNan, GuiZhou, GuangXi, GuangDong, FuJian, TaiWan, ZheJiang, JiangSu
Flavor	Pungent
Meridian Tropism	Stomach; Large Intestine
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Malpighiales 　　　　-->Family: Euphorbiaceae 　　　　　-->Genus: Croton 　　　　　　-->Species: Croton tiglium

Pair Name	Phorbol 12-myristate 13-acetate, Apicularen A
Partner Name	Apicularen A
Disease Info	[ICD-11: 2C77.Z]	Cervical cancer		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Up-regulation	Expression	CASP3	hsa836
	Up-regulation	Expression	PARP1	hsa142
	Down-regulation	Expression	PRKCA	hsa5578
	Down-regulation	Expression	TUBA1B	hsa10376
	Down-regulation	Expression	TUBB3	hsa10381
In Vitro Model	HeLa	Human papillomavirus-related cervical adenocarcinoma	Homo sapiens (Human)	CVCL_0030
Result	These results suggest that the synergy between PMA and apicularen A is involved by PKCα activation and microtubule disruption, and that may inform the development of novel approaches to treat cancer.